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Pulmonary embolism (PE) is the main cause of in-hospital loss of life and the third most frequent cause of cardiovascular demise. The clinical presentation of PE is variable, and choosing the appropriate therapy for particular person patients may be challenging. Historically, therapy of PE has involved a choice of anticoagulation, thrombolysis or surgery; however, a variety of percutaneous interventional technologies have been developed which might be under investigation in patients with intermediate-excessive-threat or high-risk PE. These interventional technologies include catheter-directed thrombolysis (with or with out ultrasound assistance), aspiration thrombectomy and combinations of the aforementioned rules. These interventional treatment options may result in a more speedy enchancment in proper ventricular operate and pulmonary and/or systemic haemodynamics specifically patients.