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Pulmonary embolism (PE) is the leading trigger of in-hospital dying and the third most frequent trigger of cardiovascular dying. The clinical presentation of PE is variable, and choosing the appropriate treatment for individual patients can be difficult. Historically, remedy of PE has involved a selection of anticoagulation, thrombolysis or surgical procedure; however, a range of percutaneous interventional applied sciences have been developed which are beneath investigation in patients with intermediate-excessive-threat or excessive-danger PE. These interventional applied sciences include catheter-directed thrombolysis (with or without ultrasound assistance), aspiration thrombectomy and mixtures of the aforementioned ideas. These interventional remedy choices may result in a more rapid improvement in right ventricular function and pulmonary and/or systemic haemodynamics specifically patients.