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Pulmonary embolism (PE) is the main cause of in-hospital death and the third most frequent cause of cardiovascular death. The clinical presentation of PE is variable, and choosing the appropriate therapy for particular person patients will be challenging. Traditionally, remedy of PE has concerned a selection of anticoagulation, thrombolysis or surgery; however, a variety of percutaneous interventional applied sciences have been developed which can be beneath investigation in patients with intermediate-high-risk or high-threat PE. These interventional applied sciences include catheter-directed thrombolysis (with or with out ultrasound help), aspiration thrombectomy and mixtures of the aforementioned principles. These interventional therapy options would possibly result in a extra rapid enchancment in right ventricular operate and pulmonary and/or systemic haemodynamics particularly patients.