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Pulmonary embolism (PE) is the main trigger of in-hospital dying and the third most frequent trigger of cardiovascular death. The clinical presentation of PE is variable, and selecting the suitable therapy for particular person patients can be challenging. Historically, therapy of PE has involved a alternative of anticoagulation, thrombolysis or surgery; nevertheless, a spread of percutaneous interventional applied sciences have been developed that are beneath investigation in patients with intermediate-excessive-risk or excessive-threat PE. These interventional technologies include catheter-directed thrombolysis (with or with out ultrasound help), aspiration thrombectomy and combos of the aforementioned rules. These interventional remedy choices would possibly lead to a more fast enchancment in proper ventricular function and pulmonary and/or systemic haemodynamics in particular patients.