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Pulmonary embolism (PE) is the leading cause of in-hospital loss of life and the third most frequent trigger of cardiovascular dying. The clinical presentation of PE is variable, and choosing the suitable treatment for particular person patients could be difficult. Historically, treatment of PE has involved a selection of anticoagulation, thrombolysis or surgery; however, a variety of percutaneous interventional applied sciences have been developed which are beneath investigation in patients with intermediate-high-threat or high-danger PE. These interventional applied sciences embody catheter-directed thrombolysis (with or without ultrasound assistance), aspiration thrombectomy and mixtures of the aforementioned principles. These interventional therapy options might result in a extra speedy improvement in right ventricular operate and pulmonary and/or systemic haemodynamics specifically patients.